Frizzled receptors signal through G proteins

G-Protein-Coupled Receptors Signal Victory

The 2012 Nobel Prize in Chemistry has been awarded to Brian K. Kobilka and Robert J. Lefkowitz for their studies of G-protein-coupled receptors. Their pioneering work over the past 40 years has provided detailed molecular insight into the structure and function of this fundamentally important family of receptors.

How activated receptors couple to G proteins.

G protein-coupled receptors (GPCRs) are involved in the control of every aspect of our behavior and physiology. This is the largest class of receptors, with several hundred GPCRs identified thus far. Examples are receptors for hormones such as calcitonin and luteinizing hormone or neurotransmitters such as serotonin and dopamine. G protein-coupled receptors can be involved in pathological proce...

Interactions between neurotensin receptors and G proteins.

Three neurotensin (NT) receptors have been cloned to date, two of which, NTS1 and NTS2, belong to the family of seven transmembrane domain receptors coupled to G proteins (GPCRs). NTS1 and NTS2 may activate multiple signal transduction pathways, involving several G proteins. However, whereas NT acts as an agonist towards all NTS1-mediated pathways, this peptide may exert either agonist or antag...

How receptors talk to trimeric G proteins.

Stimulated by hormones and sensory stimuli, serpentine receptors promote the release of GDP that is bound to the alpha subunit of trimeric G proteins and its replacement by GTP. Recent investigations have begun to define the sizes, shapes, and relative orientations of receptors and G proteins, the surfaces through which they interact with one another, and conformational changes in both sets of ...

Role of G proteins in signal transduction.